Oligonucleotide Design and Synthesis

De novo oligonucleotide synthesis (oligo synthesis) is the manufacturing of defined sequences of single-strand nucleic acids. Siriprogen Life Sciences have a variety of scales of synthesis and appropriate purification methods for custom oligonucleotide synthesis to meet your needs. We also design and assist in designing the oligos for PCR, Real-time PCR, Sanger sequencing, Next Generation Sequencing (NGS) etc. Our scales-of-synthesis ranges from 25 nM, 50 nM, 100 nM, 200 nM, etc., with the option of Desalted, Reverse-phase cartridge, PAGE and HPLC purification methods.

Custom oligonucleotide synthesis and design

Oligos with Your Choice of Modifications

CM

Chemical Modifications

  • Biotinylation
  • Digoxigenination
QM

Quencher Modification

  • Wide range of quenchers for FRET and qPCR probes
FD

Fluorescent Dye Modification

  • FAM, HEX, TAMRA, ROX, Cy3, Cy5, and more
P

Phosphorylation

  • 5′ Phosphorylation
  • 3′ Phosphorylation

Ready to Order Custom Oligos?

Our team of experts will work with you to design and synthesize high-quality oligonucleotides tailored to your research needs. From standard primers to complex modified probes — we've got you covered.